E-selectin Recombinant Rabbit mAb (SDT-1260-79)

E-selectin or endothelial-leukocyte adhesion molecule 1 (ELAM-1) is a 115 kDa endothelial transmembrane glycoprotein, which, along with other members of the selectin family, is an early mediator of endothelial-leukocyte adhesion in inflammatory states. The selectins, E-selectin and P-selectin on endothelium and L-selectin on leukocytes, bind specific ligands to promote rolling of leukocytes along the endothelial surface prior to vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1)-mediated tight binding and extravasation of leukocytes through endothelial cell junctions. Soluble form of E-selectin of reduced molecular weight is present in the supernatant of activated endothelial cells within 24 h, with further increases for up to 72 h. Low levels of E-selectin are detected in serum of normal individuals and several investigators have recently documented increased levels in patients with sepsis and other critical illnesses. There is interest in examining serum levels of E-selectin and other adhesion molecules in sepsis and other inflammatory conditions relating their measurement to outcome from critical illness.