WB result of Dopamine D(2) Receptor/D2R Recombinant Rabbit mAb
Primary antibody: Dopamine D(2) Receptor/D2R Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: Caco-2 whole cell lysate 20 µg
Lane 2: SH-SY5Y whole cell lysate 20 µg
Lane 3: PANC-1 whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 50 kDa
Observed MW: 50 kDa
Dopamine D (2) Receptor/D2R Recombinant Rabbit mAb (S-2127-37)
Dopamine D (2) Receptor/D2R Recombinant Rabbit mAb (S-2127-37)
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$100.00 USD
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Dopamine D (2) Receptor/D2R |
| Synonyms | D (2) dopamine receptor; Dopamine D2 receptor; DRD2 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P14416 |
| Clone Number | S-2127-37 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Caco-2, SH-SY5Y, PANC-1, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
The dopamine D2 receptor (D2R) is a G protein-coupled receptor encoded by the DRD2 gene, playing a crucial role in the central nervous system. It is the main target for most antipsychotic drugs and is involved in regulating various functions such as motor control, reward, and memory. D2R is coupled to the Gi subtype of G protein, inhibiting adenylyl cyclase activity. In addition to its canonical G protein signaling, D2R also signals through β-arrestin pathways, which can be selectively targeted to potentially improve therapeutic outcomes. Research has shown that D2R is involved in synaptic plasticity and memory formation in mice, and it may protect dopamine neurons from cell death in conditions mimicking Parkinson's disease.
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Western Blot
WB result of Dopamine D(2) Receptor/D2R Recombinant Rabbit mAb
Primary antibody: Dopamine D(2) Receptor/D2R Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: mouse brain lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 50 kDa
Observed MW: 50 kDa
WB result of Dopamine D(2) Receptor/D2R Recombinant Rabbit mAb
Primary antibody: Dopamine D(2) Receptor/D2R Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: rat brain lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 50 kDa
Observed MW: 50 kDa
