Cytokeratin 18 (M65) Recombinant Rabbit mAb (SDT-614-3)
Cytokeratin 18 (M65) Recombinant Rabbit mAb (SDT-614-3)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Cytokeratin 18 (M65) |
| Immunogen | Recombinant Protein |
| Accession | P05783 |
| Clone Number | SDT-614-3 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | Recognize both CK18 M30 fragment and full length CK18 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by SEC-HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Cytokeratin 18 (CK18) is a cytoskeletal protein and the main intermediate filament family member expressed in the liver and other epithelial tissues. The CK18 full-length form is released from necrotic cells, whereas a caspase-cleaved fragment is a product of the structural changes that occur during apoptosis. Soluble total and fragments of CK18 can be detected in human serum with enzyme-linked immunoassay (ELISA). The M65 assay measures total CK18, i.e., full-length and caspase-cleaved fragments of CK18 generated during cell necrosis and apoptosis, while the M30 assay detects a neoepitope created in the caspase-3 cleaved 30kDa fragment during cell apoptosis
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