Cytokeratin 18 (M30) Recombinant Rabbit mAb (SDT-616-2)
Cytokeratin 18 (M30) Recombinant Rabbit mAb (SDT-616-2)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Cytokeratin 18 (M30) |
| Synonyms | CK18-M30 |
| Immunogen | Synthetic Peptide |
| Accession | P05783 |
| Clone Number | SDT-616-2 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross reactivity against full length CK18, only recognizes CK18 M30 fragment. |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Cytokeratin 18 (CK18) is an intermediate-filament structural protein restricted to epithelial cells that becomes a specific biomarker of apoptosis when caspases 3, 6, 7 and 9 cleave it between residues 387–396, generating the soluble neo-epitope termed “M30”; this stable fragment is released into blood or culture supernatant only during programmed cell death, can be quantified by ELISA or immunohistochemistry with the M30 antibody, and thus serves as a non-invasive pharmacodynamic read-out of epithelial apoptosis in chronic liver diseases, NAFLD, viral hepatitis and cancer therapy monitoring.
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