WB result of CSNK1A1 + CSNK1A1L Recombinant Rabbit mAb
Primary antibody: CSNK1A1 + CSNK1A1L Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: MCF7 whole cell lysate 20 µg
Lane 2: HeLa whole cell lysate 20 µg
Lane 3: Jurkat whole cell lysate 20 µg
Lane 4: HCT 116 whole cell lysate 20 µg
Lane 5: U-87 MG whole cell lysate 20 µg
Lane 6: A549 whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 39 kDa
Observed MW: 34 kDa
CSNK1A1 + CSNK1A1L Recombinant Rabbit mAb (S-4407-18)
CSNK1A1 + CSNK1A1L Recombinant Rabbit mAb (S-4407-18)
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$100 USD
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | CK1α |
| Synonyms | Casein kinase I isoform alpha; CKI-alpha; CK1; Casein kinase I isoform alpha-like; CKI-alpha-like |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Nucleus |
| Accession | P48729、Q8N752 |
| Clone Number | S-4407-18 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | MCF7, HeLa, Jurkat, HCT 116, U-87 MG, A549, RAW264.7, NIH/3T3, PC-12, rat brain |
| Predicted Reactivity | C.el, Ck, Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.02% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu, Ms, Rt |
Background
CK1α (casein kinase 1 isoform alpha) is a ubiquitously expressed, constitutively active serine/threonine kinase that docks to a conserved recognition motif (pSer/pThr-X-X-S/T) in hundreds of cytoplasmic, nuclear and membrane substrates, thereby governing Wnt/β-catenin signaling by phosphorylating β-catenin for β-TrCP-mediated degradation, synchronizing circadian rhythms through PER protein turnover, regulating DNA-damage checkpoints by modifying p53 and MDM2, driving hematopoietic stem-cell maintenance via AKT pathway modulation, and serving as an essential, druggable node whose loss-of-function triggers ribosomal stress and selective apoptosis in acute myeloid leukemia cells.
Picture
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Western Blot
WB result of CSNK1A1 + CSNK1A1L Recombinant Rabbit mAb
Primary antibody: CSNK1A1 + CSNK1A1L Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: RAW 264.7 whole cell lysate 20 µg
Lane 2: NIH/3T3 whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 39 kDa
Observed MW: 34 kDa
WB result of CSNK1A1 + CSNK1A1L Recombinant Rabbit mAb
Primary antibody: CSNK1A1 + CSNK1A1L Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: PC-12 whole cell lysate 20 µg
Lane 2: rat brain lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 39 kDa
Observed MW: 34 kDa
