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CLEC7A His Tag Protein, Human

CLEC7A His Tag Protein, Human

Catalog Number: UA016064 Brand: UA BIOSCIENCE
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$245 USD
$245 USD
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Product Details

Product Specification


Species Human
Synonyms BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2
Accession Q9BXN2-2
Amino Acid Sequence

Thr 66 - Met 201 with His Tag at the N-Terminus
Expression System HEK293
Molecular Weight

15-25kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Alveolar macrophages drive lung fibrosis by sensing translocated gut fungi via Dectin-1-Raf1 axis. Immunity.
2. Targeting Dectin-1 and/or VISTA enhances anti-tumor immunity in melanoma but not colorectal cancer model. Cellular Oncology, 47(4), 1-14.
3. Dectin-1 (CLEC-7A) and Mincle (CLEC-4E) suppress protective responses of macrophages during mycobacterial infection. Journal of Leukocyte Biology, 117(11), qiaf146.

Background

CLEC7A (C-type lectin domain family 7 member A) encodes the protein Dectin-1, a key member of the C-type lectin receptor family that functions as a pattern recognition receptor central to antifungal immunity. The gene is located on human chromosome 12p13.2 and is broadly expressed in tissues including bone marrow and appendix.

Structure and Isoforms: Dectin-1 is a type II transmembrane glycoprotein of approximately 28 kDa, containing an extracellular C-type lectin-like domain (CRD), a transmembrane region, and a cytoplasmic domain. The cytoplasmic tail harbors an immunoreceptor tyrosine-based activation motif (ITAM) essential for signal transduction. Alternative splicing generates at least eight isoforms (A-H), with isoform A representing the full-length functional form; isoform B lacks the stalk region, while others harbor deletions or insertions in the CRD or transmembrane domains.

Picture

SDS-PAGE

2μg (R: reducing condition, N: non-reducing condition).

SEC-HPLC

The purity of CLEC7A His Tag Protein, Human is more than 95% determined by SEC-HPLC.