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CLEC7A His Tag Protein, Cynomolgus

CLEC7A His Tag Protein, Cynomolgus

Catalog Number: UA016065 Brand: UA BIOSCIENCE
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$245 USD
$245 USD
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Product Details

Product Specification


Species Human
Synonyms BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2
Accession A0A2K5UXY6
Amino Acid Sequence

Thr 100 - Met 281 with His Tag at the N-Terminus
Expression System HEK293
Molecular Weight

35-40kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive hybridization. Journal of Biological Chemistry, 275(26), 20157-20167.
2. The human beta-glucan receptor is widely expressed and functionally equivalent to murine dectin-1. Journal of Immunology, 167(8), 4567-4573.
3. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nature Immunology, 8(1), 31-38.

Background

The CLEC7A gene in cynomolgus macaque (Macaca fascicularis) encodes a Dectin-1 protein highly homologous to its human counterpart. According to the KEGG pathway database, the cynomolgus macaque CLEC7A gene is designated with the identifier 103218570, and the encoded protein is classified as a C-type lectin receptor family member.

Structural and Functional Homology: As a non-human primate model, cynomolgus macaque Dectin-1 is highly conserved in structure and function with the human protein. It is a type II transmembrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic ITAM motif. This receptor recognizes pathogen-derived β-glucans, activates downstream signaling cascades, induces inflammatory cytokines and chemokines, and triggers innate and adaptive immune responses against pathogens

Picture

SDS-PAGE

2μg (R: reducing condition, N: non-reducing condition).

SEC-HPLC

The purity of CLEC7A His Tag Protein, Cynomolgus is more than 95% determined by SEC-HPLC.