2μg (R: reducing condition, N:non-reducing condition).
CD97 Fc Chimera Protein, Mouse
CD97 Fc Chimera Protein, Mouse
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$235 USD
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | ADGRE5 |
| Accession | AAH06676.1 |
| Amino Acid Sequence | Gln24-His384 with hIgG1 Fc Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 70-100kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Hamann J, van Zeventer C, Bijl A, Molenaar C, Tesselaar K, van Lier RA. Molecular cloning and characterization of mouse CD97. Int Immunol. 2000 Apr;12(4):439-48. |
Background
Mouse CD97 (mCD97) is a member of the adhesion G protein-coupled receptor (aGPCR) family. Its extracellular region undergoes alternative splicing to generate isoforms containing different numbers of EGF-like domains and exists in a glycosylated form. Its N-terminal domain binds to the ligand CD55 (decay-accelerating factor), while the transmembrane region mediates signal transduction. Functionally, CD97 acts as a mechanosensor that regulates the localization of splenic marginal zone B cells and T cell-independent antibody production by sensing blood flow shear stress, and also maintains dendritic cell homeostasis. Additionally, it participates in granulocyte migration, hematopoietic stem cell differentiation, and tumor microenvironment remodeling. Clinically, CD97 is highly expressed in malignant tumors such as gastric cancer, where its small isoform promotes tumor invasion and metastasis, serving as both a prognostic marker and a potential therapeutic target. Moreover, its immunomodulatory roles in inflammatory diseases offer new avenues for intervention strategies.
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SDS-PAGE
ELISA
Immobilized CD55/DAF His Tag Protein, Mouse(Cat. No. UA010737) at 0.5μg/mL(100μL/well) can bind CD97 Fc Chimera Protein, Mouse(Cat. No. UA016177) with EC50 of 6.82-10.46 ng/mL.
