WB result of L-selection Recombinant Rabbit mAb
Primary antibody: L-selection Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: HeLa whole cell lysate 20 µg
Lane 2: Jurkat whole cell lysate 20 µg
Negative control: HeLa whole cell lysate
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 42 kDa
Observed MW: 50~80 kDa
CD62L(L-Selection) Recombinant Rabbit mAb (S-1164-33)
CD62L(L-Selection) Recombinant Rabbit mAb (S-1164-33)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | L-selection |
| Synonyms | CD62 antigen-like family member L; Leukocyte adhesion molecule 1 (LAM-1); Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1 (LECAM1); Lymph node homing receptor; TQ1; gp90-MEL; CD62L; SELL; LNHR, LYAM1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P14151 |
| Clone Number | S-1164-33 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | Jurkat |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
L-selectin, also known as CD62L, is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Its function in leukocyte trafficking is highlighted by its role in lymphocyte homing to secondary lymphoid tissues. It mediates the tethering and rolling of lymphocytes on high endothelial venules (HEVs) in peripheral lymph nodes via interactions with glycoproteins expressing sLex epitopes. This process is essential for the proper functioning of the immune system, allowing for the recirculation of lymphocytes and their migration to sites of inflammation. In addition to its role in immune cell trafficking, L-selectin has been implicated in the adhesion of blastocysts to the endometrium during the implantation process in the female reproductive tract. It also plays a role in the recruitment of leukocytes during inflammation and in the homing of lymphocytes.
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Western Blot
