Flow cytometric analysis of human PBMCs (peripheral blood mononuclear cells) labeled with anti - Mouse CD41 antibody at 1/200 dilution (1 μg) / (right panel) compared with a Mouse IgG1, κ Isotype Control / (left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
CD41 Mouse mAb (S-3057-8)
CD41 Mouse mAb (S-3057-8)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD41 |
| Synonyms | Integrin alpha-IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; GP2B; ITGAB; ITGA2B |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P08514 |
| Clone Number | S-3057-8 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | IHC-P, FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.02% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:2000 | Hu |
| FCM | 1:200 | Hu |
Background
CD41a, also known as platelet glycoprotein IIb, is a crucial component of the GPIIb/IIIa complex on the platelet membrane. It is a calcium-dependent protein that pairs with CD61 to form the functional fibrinogen receptor, playing a vital role in platelet aggregation and blood clotting. This complex is primarily expressed in normal platelets and megakaryocytes. Additionally, CD41a is one of the first cell surface markers indicative of hematopoietic commitment and is involved in maintaining hematopoietic stem cell activity during embryonic development.
Picture
Picture
FC
Immunohistochemistry
IHC shows positive staining in paraffin-embedded human kidney. Anti-CD41 antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human liver. Anti-CD41 antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human placenta. Anti-CD41 antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human spleen. Anti-CD41 antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
