Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. The EC50 for this effect is less than 70ng/ml
CD31/PECAM-1 His Tag Protein, Human
CD31/PECAM-1 His Tag Protein, Human
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$192 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | PECAM1, FLJ34100, FLJ58394 |
| Accession | P16284 |
| Amino Acid Sequence | Gln28-Lys601 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 85-100kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Cao LL, Yang ZG, Qi WH, Zhang H, Bi Y, Shan Y, Cui XW, Jiang F. A preliminary study on ultrasound techniques applied to evaluate the curative effect of botulinum toxin type a in hypertrophic scars. Heliyon. 2024 Jul 19;10(15):e34723. |
Background
Cluster of Differentiation 31 (CD31), also known as Platelet Endothelial Cell Adhesion Molecule (PECAM-1), is a 130-kDa transmembrane glycoprotein. It is expressed by a variety of cell types including endothelial cells, platelets, macrophages, Kupffer cells, granulocytes, T/NK cells, lymphocytes, megakaryocytes, osteoclasts, and neutrophils. CD31 is also found in certain tumors and is the sole CAM family member present on platelets.
CD31 is pivotal in the clearance of aged neutrophils and in the process of tissue regeneration. The protein facilitates cell adhesion through homotypic or heterotypic interactions, either by binding to itself or by engaging with the leukocyte integrin αvβ3. These properties enable CD31 to contribute to neutrophil recruitment during inflammatory responses and to the transendothelial migration of leukocytes. Additionally, CD31 plays a significant role in cardiovascular development.
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Bioactivity
SDS-PAGE
1μg (R: reducing condition).
SEC-HPLC
The purity of CD31/PECAM-1 His Tag Protein, Human is more than 95% determined by SEC-HPLC.
