2μg (R: reducing condition, N: non-reducing condition).
CD300f/LMIR3/IREM-1 His Tag Protein, Human
CD300f/LMIR3/IREM-1 His Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | CD300f, LMIR3, CLM1, IGSF13, IREM-1, NKIR |
| Accession | Q8TDQ1-1 |
| Amino Acid Sequence | Thr20-Ser156, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 20-35kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 1*PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Clark, G.J. et al. (2009) Trends Immunol. 30:209. Sui, L. et al. (2004) Biochem. Biophys. Res. Commun. 319:920. Alvarez-Errico, D. et al. (2004) Eur. J. Immunol. 34:3690. Korver, W. et al. (2009) Leukemia 23:1587. |
Background
LMIR3, also known as CD300f, CD300LF, IREM-1, CLM-1, IgSF13, DIgR1, and MAIR-V, is a 50-60 kDa glycoprotein member of the immunoglobulin superfamily. Human LMIR3 consists of a 137 amino acid (aa) extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane segment, and a 113 aa cytoplasmic domain that contains multiple immunoreceptor tyrosine-based inhibitory motifs (ITIMs) or ITIM-like sequences. Within the ECD, human LMIR3 shares 43% aa sequence identity with mouse and rat LMIR3. LMIR3 is expressed on the surface of dendritic cells, monocytes, granulocytes, and mast cells as well as on acute myeloid leukemia (AML) blasts. LMIR3 is up-regulated on monocytes surrounding experimentally-induced spinal cord demyelination and functions as a negative regulator of inflammation in the CNS.
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SDS-PAGE
SEC-HPLC
