1μg (N: non-reducing condition).
CD27 Ligand/CD70 His&Flag Tag Trimer design Protein, Human
CD27 Ligand/CD70 His&Flag Tag Trimer design Protein, Human
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$276 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | CD70, CD27LG, TNFSF7, TNFSF7G, CD27L |
| Accession | P32970-1 |
| Amino Acid Sequence | Gly54-Pro193 with His&Flag Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 57-60kDa (Non-Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | His Tag, Flag Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS PH7.4 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Yang Y, Wang Y, Jin X, He W. Single-cell RNA-sequencing reveals cellular heterogeneity and immune microenvironment characteristics between ocular adnexal mucosa-associated lymphoid lymphoma and IgG4-related ophthalmic disease. Front Immunol. 2025 Feb 26;16:1508559. |
Background
Cluster of Differentiation 70 (CD70), also known as CD27 ligand (CD27L/CD27LG), TNFSF7, or TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily. It is expressed on activated T and B lymphocytes and mature dendritic cells. CD70 binds to its receptor CD27, inducing T-cell priming, effector functions, differentiation, and memory formation. This interaction is critical for T-cell activation, co-stimulated T-cell proliferation, and the generation of cytolytic T-cells. CD70 on T cells provides essential co-stimulatory signals for T-cell proliferation and clonal expansion, promoting effector T-cell formation. In mouse B cells, CD70 inhibits terminal differentiation into plasma cells and enhances memory B-cell responses. Additionally, CD70 stimulates NK cell proliferation and IFNγ production.
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SDS-PAGE
ELISA
Immobilized CD27 Ligand/CD70 His&Flag Tag Protein, Human (Cat. No. UA011195) at 2.0μg/mL (100μL/well) can bind CD27/TNFRSF7 Fc Chimera Protein, Human (Cat. No. UA010395) with EC50 of 33.15-66.26ng/mL.
