2μg (R: reducing condition, N: non-reducing condition).
CD24 mFc Chimera Protein, Human
CD24 mFc Chimera Protein, Human
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$256 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Signal transducer CD24; Ly-52; HAS; Nectadrin; R13-Ag; CD24; CD24A |
| Accession | P25063-1 |
| Amino Acid Sequence | Ser27-Gly59 with Mouse IgG2a Fc at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 40-55kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | Mouse IgG2a Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35. 2.Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12. |
Background
Cluster of Differentiation 24 (CD24) is a mucin-type glycoprotein linked to the cell membrane via glycosylphosphatidylinositol (GPI). It is expressed on the surface of B-cells. Elevated levels of CD24 expression have been observed in various epithelial cancers, including ovarian, breast, non-small cell lung, prostate, and pancreatic cancers. CD24 plays a role in molecular adhesion and the spread of metastatic tumors, and it serves as a normal receptor for P-selectin. The CD24/P-selectin interaction may be significant in the dissemination of tumor cells by facilitating their interaction with platelets and endothelial cells. Furthermore, CD24 has been considered a potential tumor marker.
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SDS-PAGE
ELISA
Immobilized CD24 mFc Chimera Protein, Human (Cat. No. UA011100) at 2.0μg/mL (100μL/well) can bind CD24 Recombinant Rabbit mAb (S-974-13) (Cat. No. S0B0725) with an EC50 of 0.92-2.24ng/mL.
