2μg (R: reducing condition, N: non-reducing condition).
CCL1/I-309 Protein, Human
CCL1/I-309 Protein, Human
Price:
Regular price
$115 USD
Regular price
Sale price
$115 USD
Unit price
per
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | C-C motif chemokine 1, Small-inducible cytokine A1, T lymphocyte-secreted protein I-309 |
| Accession | P22362 |
| Amino Acid Sequence | Lys24-Lys96 |
| Expression System | E.coli |
| Molecular Weight | 10-13 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | J Exp Med. 2013 Jul 29;210(8):1509-28. |
Background
CCL1 (Chemokine (C-C motif) Ligand 1), also known as I-309 in humans and TCA-3 in mice, is a small glycoprotein belonging to the CC chemokine β-subfamily. Human CCL1 shares ~42% amino acid identity with mouse TCA-3; both contain a unique extra pair of cysteine residues not found in most other chemokines.
In scientific and industrial fields, CCL1 mainly is focused on CCR8-targeted immunotherapy. CCR8 is an attractive drug target due to its restricted expression pattern (primarily Tregs and Th2 cells) and single human ligand (CCL1), minimizing off-target effects. CCL1 levels are also elevated in bronchoalveolar lavage of asthmatic patients and serum of atopic dermatitis patients .
Picture
Picture
SDS-PAGE
RP-HPLC
>95% as determined by RP-HPLC.
