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BTN1A1/Butyrophilin Fc Chimera Protein, Human

BTN1A1/Butyrophilin Fc Chimera Protein, Human

Catalog Number: UA011184 Brand: UA BIOSCIENCE
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$185 USD
$185 USD
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Product Details

Product Specification


Species Human
Synonyms BTN,BT,BTN1
Accession Q13410-1
Amino Acid Sequence

Ala27-Arg242 with hIgG1 Fc Tag at the C-Terminus
Expression System HEK293
Molecular Weight

55-70kDa (Reducing)
Purity ＞95% by SDS-PAGE & > 95% SEC-HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Chen B, Li K, Wang X, Zhang W, Han S, Zhang Y, Wang Y, Pang X, Xie Q, Lu J, Jiang S, Zhang S, Lv J. Dynamic Variations in Endogenous Peptides in Chinese Human Milk Across Lactation and Geographical Regions. Nutrients. 2025 Sep 30;17(19):3131.
2.Xie M, Yuan W, Tian Z, Tan L, Zhou H, Yang Q, Zhou L, Shan W, Luo J, Fan X. Advances in isolation, composition, properties and applications of milk fat globule membrane proteins: A review. Food Res Int. 2025 Dec;221(Pt 3):117422.

Background

BTN1A1 (also known as butyrophilin subfamily 1 member A1) is a 55 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. Its structure includes extracellular IgV/IgC domains, a transmembrane region, and a cytoplasmic tail containing a B30.2 domain. Functionally, the B30.2 domain binds to xanthine oxidoreductase (XOR) to regulate milk fat globule secretion, while also serving as an intracellular phosphoantigen sensor to activate γδ T cells. Additionally, BTN1A1 inhibits CD4+ T cell proliferation, reduces the secretion of cytokines such as IL-2 and IFN-γ, and demonstrates protective effects in experimental autoimmune encephalomyelitis (EAE) models. Given its structural similarity to the B7 family and its involvement in immune regulation, BTN1A1 represents a potential novel co-stimulatory/inhibitory molecule and a promising therapeutic target for autoimmune and immune-related diseases.

Picture

SDS-PAGE

1μg (R: reducing condition, N:non-reducing condition).

SEC-HPLC

The purity of BTN1A1/Butyrophilin Fc Chimera Protein, Human is more than 95% determined by SEC-HPLC.