Biotinylated SIRP-α Fc Chimera Protein, Human

Catalog Number: UA010008 Brand: UA BIOSCIENCE

Price:

$560 USD

Size: 25μg 100μg

Quantity:

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Product Details

Product Specification

Species	Human
Synonyms	Biotinylated SIRP-α Fc Chimera protein ;BIT, BITbrain-immunoglobulin-like molecule with tyrosine-based activation motifs, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172a antigen, CD172a, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MFR, MFRtyrosine phosphatase SHP substrate 1, MyD-1 antigen, MYD1, MYD-1, P84, protein tyrosine phosphatase, non-receptor type substrate 1, PTPNS1, SHP substrate 1, SHPS1, SHPS-1, SHPS1CD172A, signal-regulatory protein alpha, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, SIRP alpha, SIRPA, SIRPalpha, Sirp-alpha-1, SIRPalpha2, Sirp-alpha-2, Sirp-alpha-
Accession	P78324
Amino Acid Sequence	Glu31-Arg370, with C-terminal Human IgG1 Fc&Avi tag
Expression System	HEK293
Molecular Weight	150 kDa(Non-reducing)
Purity	＞90%, by SDS-PAGE under Non-reducing conditions
Endotoxin	<0.1EU/μg
Conjugation	Biotin
Tag	Human Fc Tag
Physical Appearance	Lyophilized powder
Storage Buffer	PBS pH7.2，5% trehalose
Reconstitution	Reconstitute at less than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.

Background

Signal regulatory protein α (SIRPα), also known as SHPS-1, is a transmembrane protein. SIRPα is highly expressed on the membranes of myeloid cells, such as macrophages, granulocytes, monocytes, and myeloid dendritic cells. It regulates cell migration and phagocytic activity, as well as immune homeostasis and neural network formation.

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Bioactivity

Immobilized Human CD47 Fc Chimera(Cat. No. UA010006) at 1 μg/mL (100 μL/well) can bind Biotinylated SIRP-α Fc Chimera, Human (Cat. No. UA010008) with EC50 of 0.057 μg/mL.