2μg (R: reducing condition, N: non-reducing condition).
Biotinylated PSMA/FOLH1 His & Avi Tag Protein, Cynomolgus
Biotinylated PSMA/FOLH1 His & Avi Tag Protein, Cynomolgus
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$560 USD
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Product Details
Product Details
Product Specification
| Species | Cynomolgus |
| Synonyms | FOLH1, PSMA, GIG27, FOLH, NAALAD1, PSM, NAALADase I, GCPII, FGCP |
| Accession | A0A2K5VNZ0 |
| Amino Acid Sequence | Lys44-Ala750 with His Tag & Avi Tag at N-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 95-110kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Chen L, Cheng S, Zhu D, Bao G, Wang Z, Deng X, Liu X, Ma X, Zhao J, Zhu L, Zhu X. Synthesis and Preclinical Evaluation of Dual-Specific Probe Targeting Glypican-3 and Prostate-Specific Membrane Antigen for Hepatocellular Carcinoma PET Imaging. Mol Pharm. 2024 Dec 10. |
Background
Prostate-specific membrane antigen (PSMA), also known as Folate hydrolase 1 (FOLH1), Glutamate carboxypeptidase 2 (GCP2), or N-acetylated-alpha-linked acidic dipeptidase I (ALAD1), is a member of the peptidase M28 family and M28B subfamily. PSMA is stable at pH levels greater than 6.5 and is a type II transmembrane zinc metallopeptidase with high expression in the nervous system, prostate, kidney, and small intestine.
PSMA forms homodimers, binds two zinc ions per subunit, and is required for its ALADase activity. It exhibits catalytic activity involved in the release of an unsubstituted, C-terminal glutamyl residue, typically from sequences such as Ac-Asp-Glu or folylpoly-gamma-glutamates. PSMA possesses both folate hydrolase and N-acetylated-alpha-linked acidic dipeptidase (ALADase) activities, showing a preference for tri-alpha-glutamate peptides.
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SDS-PAGE
ELISA
Immobilized Anti-Human PSMA (Rosopatamab) at 2.0μg/mL (100μL/well) can bind Biotinylated PSMA/FOLH1 His & Avi Tag Protein, Cynomolgus (Cat. No. UA011140) with EC50 of 7.52-12.70ng/mL.
