2μg (R: reducing condition).
Biotinylated LILRB2/CD85d/ILT4 Fc&Avi Tag Protein, Human
Biotinylated LILRB2/CD85d/ILT4 Fc&Avi Tag Protein, Human
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$540 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | LIR2, MIR10, ILT-4 |
| Accession | Q8N423 |
| Amino Acid Sequence | Gly24-His458 with Human IgG1 Fc & Avi Tag at the C-terminus |
| Expression System | HEK293 |
| Molecular Weight | 80-95 kDa(Reducing) |
| Purity | >95% by SDS-PAGE;90% by SEC-HPLC |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, Human IgG1 Fc |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS PH7.4 5% trehalose |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Bai R, Guo J. SPI1 upregulated LILRB2 to enhance the immunosuppressive phenotype of LPS-tolerant macrophages by inhibiting TLR8-mediated MyD88/NF-κB signaling. Biol Direct. 2025 Jun 23;20(1):73. |
Background
ILT4 (LILRB2) is an inhibitory receptor of the LIR-B subfamily, featuring two or four extracellular Ig domains, a transmembrane segment, and two to four cytoplasmic ITIMs. It binds class I MHC molecules (HLA-A, -B, -C, -G) and competes with CD8A for these ligands. LILRB2 dampens FCGR1A-mediated phosphorylation and Ca²⁺ mobilization, thereby restraining inflammatory responses and cytotoxicity to limit autoreactivity and focus immune responses.
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SDS-PAGE
SEC-HPLC
The purity of Biotinylated LILRB2/CD85d/ILT4 Fc&Avi Tag Protein, Human is greater than 90% as determined by SEC-HPLC.
ELISA
Immobilized Rabbit Anti-Human ILT4 (CD85d) Antibody (S-281-50) at 1.0μg/mL (100μL/well) can bind Biotinylated LILRB2/CD85d/ILT4 Fc&Avi Tag Protein, Human (Cat. No. UA011257) with EC50 of 7.00-8.22 ng/mL.
