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Biotinylated IL-2R gamma/CD132 Fc&Avi Tag Protein, Human

Biotinylated IL-2R gamma/CD132 Fc&Avi Tag Protein, Human

Catalog Number: UA011260 Brand: UA BIOSCIENCE
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$850 USD
$850 USD
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Product Details

Product Specification


Species Human
Synonyms IL-2 receptor subunit gamma, IL2RG
Accession P31785-1
Amino Acid Sequence

Leu23-Asn254 with hIgG Fc&Avi Tag at the C-Terminus
Expression System HEK293
Molecular Weight 70-100kDa (Reducing)
Purity ＞95% by SDS-PAGE&HPLC
Conjugation Biotin
Tag Human IgG1 Fc, Avi Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, pH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Kim JY, Mayatepek E, Seyfarth J, Jacobsen M. High common-γ cytokine receptor levels promote expression of Interleukin-2/Interleukin-7 receptor α-chains with implications on T-cell differentiation and function. Immunology. 2024 Sep;173(1):93-105.
2.Andreu-Ballester JC, Hurtado-Marcos C, García-Ballesteros C, Pérez-Griera J, Izquierdo F, Ollero D, Jiménez A, Gil-Borrás R, Llombart-Cussac A, López-Chuliá F, Cuéllar C. Decreased gene expression of interleukin 2 receptor subunit γ (CD132) in tissues of patients with Crohn's disease. World J Gastroenterol. 2025 Mar 28;31(12):97120. 
3.Montorfani J, Hatterer E, Chatel L, Lesnier A, Viandier A, Daubeuf B, Nouveau L, Malinge P, Calloud S, Masternak K, Ferlin W, Fischer N, Jandus C, Shang L. Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies. J Immunother Cancer. 2025 Mar 25;13(3):e010650. 

Background

IL-2 Rγ/CD132 is a transmembrane protein belonging to the type I cytokine receptor family, characterized by a highly conserved extracellular WSXWS motif, a transmembrane region, and an intracellular domain containing Box1/Box2 motifs. It serves as the shared signaling chain for six cytokines: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Through its intracellular domain, it couples with signaling molecules such as JAK3 and STAT5, playing an indispensable core role in T/NK cell development, lymphocyte homeostasis, and immune regulation. The clinical significance of this molecule is substantial—mutations in its gene cause X-linked severe combined immunodeficiency (X-SCID). Therapeutic strategies targeting this molecule have been translated in three key ways: gene therapy encoding γc (e.g., Strimvelis) has received clinical approval; CD132-targeting bispecific antibodies selectively activate the common receptor complex within the tumor microenvironment to achieve anti-tumor immunity while avoiding systemic toxicity; and engineered IL-2/antibody biased complexes modulate CD132-dependent signaling preferences to expand regulatory T cells for transplant tolerance and autoimmune disease treatment.

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SDS-PAGE

2μg (R: reducing condition, N:non-reducing condition).

SEC-HPLC

The purity of Biotinylated IL-2R gamma/CD132 Fc&Avi Tag Protein, Human is more than 95% determined by SEC-HPLC.