1μg (R: reducing condition).
Biotinylated ErbB2/Her2 Fc&Avi Tag Protein, Human
Biotinylated ErbB2/Her2 Fc&Avi Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | CD340, ERBB2, NEU, NGL, MLN19, TKR1 |
| Accession | P04626-1 |
| Amino Acid Sequence | Thr23-Thr652 with Human IgG1 Fc & Avi Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 60-80kDa (Reducing) |
| Purity | > 95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Antonio C. Wolff; M. Elizabeth H. Hammond; JaredN. Schwartz; Karen L. Hagerty; D. Craig Allred; Richard J. Cote; MitchellDowsett; Patrick L. Fitzgibbons; Wedad M. Hanna; Amy Langer; Lisa M. McShane;Soonmyung Paik; Mark D. Pegram; Edith A. Perez; Michael F. Press; AnthonyRhodes; Catharine Sturgeon; Sheila E. Taube; Raymond Tubbs; Gail H. Vance; Marcvan de Vijver; Thomas M. Wheeler; Daniel F. Hayes: American Society of ClinicalOncology/College of American Pathologists Guideline Recommendations for HumanEpidermal Growth Factor Receptor 2 Testing in Breast Cancer, Arch Pathol Lab Med (2007) 131 (1): 18–43. |
Background
Human Epidermal Growth Factor Receptor 2 (HER2), also known as ERBB2, HER-2, HER-2/neu, NEU, NGL, TKR1, and c-erbB-2, is a protein associated with increased aggressiveness in breast cancers. HER2 is a member of the ErbB protein family, also known as the epidermal growth factor receptor family. It is a cell membrane-bound receptor tyrosine kinase that plays a role in signal transduction pathways leading to cell growth and differentiation.
The human ErbB2 protein consists of 1255 amino acids, including a 22 amino acid signal sequence, a 630 amino acid extracellular domain (ECD), a 23 amino acid transmembrane region, and a 580 amino acid cytoplasmic domain. HER2 is involved in development, cancer progression, communication at the neuromuscular junction, and the regulation of cell growth and differentiation. Phosphoinositide 3-kinase has been implicated in ErbB2 signal transduction, and the cytoplasmic domain of ErbB2 has been shown to interact with beta-catenin and plakoglobin.
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SDS-PAGE
ELISA
Immobilized Anti-HER2 Monoclonal Antibody (Trastuzumab) (Cat. No. UA011035) at 2.0μg/mL (100μL/well) can bind Biotinylated ErbB2/Her2 Fc&Avi Tag Protein, Human (Cat. No. UA011015) with EC50 of 10.71-23.01 ng/mL.
