Biotinylated Annexin V His&Avi Tag Protein, Human

Annexin V (also known as Annexin A5) is a calcium-dependent phospholipid-binding protein with a molecular weight of approximately 35 kDa. Its structure comprises four highly conserved repeat domains (each containing approximately 70 amino acids), with a core region harboring binding sites for both calcium ions and phosphatidylserine (PS). Functionally, Annexin V binds with high affinity to PS exposed on the outer leaflet of apoptotic cells, serving as the "gold standard" tool for apoptosis detection; meanwhile, it also exhibits multiple biological activities including anticoagulation, immune modulation, and tissue protection. In recent years, the clinical applications of Annexin V have expanded from simple apoptosis detection to targeted therapeutics—by leveraging its specific recognition of apoptotic cells, researchers have conjugated Annexin V with drugs, nanoparticles, or radionuclides for tumor-targeted drug delivery, neuroprotection following ischemic stroke, and cardiovascular disease treatment, demonstrating broad prospects in translational medicine.