Flow cytometric analysis of CD193 expression on C57BL/6 mouse peripheral blood cells. C57BL/6 mouse peripheral blood cells were stained with Pacific Blue™ Rat Anti-Mouse Ly6G/Ly6C Antibody and either Biotin Rat IgG2a, κ Isotype Control (left panel) or SDT Biotin Rat Anti-Mouse CD193 Antibody (right panel) at 2 μl/test followed by Sav-APC. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Biotin Rat Anti-Mouse CD193 Antibody (S-R699)
Biotin Rat Anti-Mouse CD193 Antibody (S-R699)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD193 |
| Synonyms | Probable C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3; Macrophage inflammatory protein 1-alpha receptor-like 2 (MIP-1 alpha RL2); Cmkbr1l2; Cmkbr3 |
| Location | Cell membrane |
| Accession | P51678 |
| Clone Number | S-R699 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse peripheral blood cells |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Ms |
Background
CD193, also known as C-C motif chemokine receptor 3 (CCR3), is a member of the G protein-coupled receptor (GPCR) family, characterized by its seven-transmembrane structure. It is a high-affinity receptor for various chemokines, including eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). CD193 is highly expressed on eosinophils, basophils, and airway epithelial cells, and is also detected in CD4+ T cells, mast cells, monocytes, platelets, and CD34+ hematopoietic progenitor cells. This receptor plays a crucial role in mediating the migration and activation of eosinophils and other inflammatory cells, contributing to allergic responses and inflammatory processes in conditions such as asthma and allergic rhinitis. Additionally, CD193 has been identified as a co-receptor for HIV-1 entry into cells.
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