Flow cytometric analysis of human CD88 expression on human peripheral blood cells. Human peripheral blood cells were stained with Brilliant Violet 421™ Mouse Anti-Human CD11b Antibody and either Biotin Rabbit IgG Isotype Control (left panel) or SDT Biotin Rabbit Anti-Human CD88 Antibody (right panel) at 5 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
Biotin Rabbit Anti-Human CD88 Antibody (S-1921-43)
Biotin Rabbit Anti-Human CD88 Antibody (S-1921-43)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | CD88 |
| Synonyms | C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor (C5a-R; C5aR); C5AR; C5R1; C5AR1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P21730 |
| Clone Number | S-1921-43 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Isotype Control | S0B8273 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood cells |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD88, also known as C5a receptor 1 (C5aR1), is a G protein-coupled receptor that plays a crucial role in the immune system. It is primarily expressed on various immune cells, including neutrophils, monocytes, macrophages, and some endothelial cells. The binding of the anaphylatoxin C5a to CD88 triggers a wide range of biological responses, such as chemotaxis, degranulation, and the release of pro-inflammatory cytokines, which are essential for the recruitment of immune cells to sites of infection or inflammation. Additionally, CD88-mediated signaling can enhance phagocytosis and promote the activation of the immune response. Dysregulation of CD88 function has been implicated in several inflammatory and autoimmune diseases, making it a potential therapeutic target for interventions aimed at modulating immune responses.
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