Flow cytometric analysis of Human CD24 expression on Human PBMCs (human peripheral blood mononuclear cells). Human PBMCs were stained with Alexa Fluor® 647 Mouse Anti-Human CD19 Antibody and either Biotin Rabbit IgG Isotype Control (left panel) or SDT Biotin Rabbit Anti- Human CD24 Antibody (right panel) at 5 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
Biotin Rabbit Anti-Human CD24 Antibody (S-974-13)
Biotin Rabbit Anti-Human CD24 Antibody (S-974-13)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | CD24 |
| Synonyms | Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24A |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P25063 |
| Clone Number | S-974-13 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Isotype Control | S0B8273 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD24 is a highly glycosylated cell surface protein that is anchored to the cell membrane via a glycosyl-phosphatidylinositol (GPI) anchor. It is widely expressed in various cell types, including hematopoietic cells such as B cells, T cells, granulocytes, dendritic cells, and macrophages, as well as non-hematopoietic cells like keratinocytes and neurons. CD24 plays a crucial role in immune cell maturation and regulation of immune responses. In cancer, CD24 is overexpressed on tumor cells and interacts with the inhibitory receptor Siglec-10 on immune cells, helping tumor cells evade immune detection and attack. This interaction has led to its exploration as a potential target for cancer immunotherapy, with promising results from clinical trials of monoclonal antibodies and other targeted therapies.
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