Biotin Mouse Anti-Human MCP-1/CCL2 Antibody (5D3-F7)

MCP-1, or Monocyte Chemoattractant Protein-1 (also known as CCL2), is a key member of the CC chemokine subfamily. It is primarily secreted by various cell types, including monocytes and endothelial cells. Its core function is to potently attract and activate monocytes by binding to its receptor CCR2, guiding them to cross the vascular endothelium and migrate to sites of inflammation or injury. While MCP-1 is indispensable for host defense and immune surveillance, its overexpression or aberrant expression drives the pathology of numerous diseases. For instance, in osteoarthritis, it promotes the polarization of monocytes toward pro-inflammatory M1-type macrophages; it also plays significant roles in atherosclerosis, tumor microenvironment remodeling, and autoimmune diseases such as systemic lupus erythematosus. Furthermore, recent studies have uncovered non-chemotactic functions of MCP-1 in the nervous system, where it can enhance excitatory synaptic transmission in neurons through specific signaling pathways, indicating its complex involvement in neuroinflammation and pain modulation.