Biotin Mouse Anti-Human CD49b Antibody (S-6067)

CD49b (also known as integrin α2 or the VLA-2 α chain) is a 150 kDa type I transmembrane glycoprotein that, as a member of the integrin family, non-covalently associates with the β1 subunit (CD29) to form the α2β1 heterodimer. It primarily serves as a receptor for collagen, laminin, and fibronectin, mediating cell adhesion to the extracellular matrix as well as lymphocyte activation. CD49b is expressed on a variety of cell types, including NK cells, a subset of splenic CD4⁺ T cells, NKT cells, intestinal intraepithelial lymphocytes, epithelial cells, and platelets. Physiologically, α2β1 is critical for platelet adhesion to collagen and thrombus formation, and its gene polymorphisms (such as 807C>T) are associated with differences in platelet surface receptor density and the risk of myocardial infarction and stroke in young individuals. Recent studies have also revealed that CD49b plays an immunomodulatory role in the tumor microenvironment: CD49b on the surface of tumor cells suppresses the expression of chemokines such as CXCL10 through the FAK signaling pathway, thereby limiting CD8⁺ T cell infiltration; targeting CD49b can enhance the antitumor efficacy of PD-L1 blockade therapy. In addition, CD49b also serves as one of the markers of activated regulatory T cells, participating in the regulation of their migration to inflammatory sites and their suppressive function.