Flow cytometric analysis of CD371 expression on human Peripheral Blood cells. Human Peripheral Blood cells were stained with either Biotin Mouse IgG2a, k Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD371 Antibody (right panel) at 5 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
Biotin Mouse Anti-Human CD371 Antibody (S-2850)
Biotin Mouse Anti-Human CD371 Antibody (S-2850)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD371 |
| Synonyms | C-type lectin domain family 12 member A; C-type lectin-like molecule 1 (CLL-1); Dendritic cell-associated lectin 2 (DCAL-2); Killer cell C-type lectin-like receptor L1 (hKLRL1); Myeloid inhibitory C-type lectin-like receptor (MICL); CLL1; DCAL2; KLRL1; MICL; CLEC12A |
| Location | Cell membrane |
| Accession | Q5QGZ9 |
| Clone Number | S-2850 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Isotype Control | S0B5432 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD371, also known as CLEC12A, is a type II transmembrane protein with extracellular C-type lectin domains, primarily expressed on myeloid cells. It is a potential myeloid cancer stem cell marker and is considered a target for antibody-based or chimeric antigen receptor T-cell therapies. CD371 is particularly associated with DUX4-rearranged leukemia, where it is highly expressed and serves as a unique cell surface marker. Its expression is also linked to “switch” acute lymphoblastic leukemia (ALL), which has a tendency to switch to monocyte-like cells upon corticosteroid treatment.
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