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Biotin Mouse Anti-Human CD335 Antibody (S-R660)

Biotin Mouse Anti-Human CD335 Antibody (S-R660)

Catalog Number: S0B8664 Application: FCM Reactivity: Hu Conjugation: Biotin Brand: Starter
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Product Details

Product Specification


Host Mouse
Antigen CD335
Synonyms Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein (NK-p46; NKp46; hNKp46); LY94; NCR1
Location Cell membrane
Accession O76036
Clone Number S-R660
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein G
Concentration 0.2 mg/ml
Conjugation Biotin
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1.25μl per million cells in 100μl volume Hu

Background

CD335, also known as NKp46 or NCR1, is a type I transmembrane glycoprotein selectively expressed on both resting and activated natural killer (NK) cells that functions as a key cytotoxicity-activating receptor by recognizing pathogen-derived or tumor-associated ligands and subsequently coupling with the ITAM-bearing adaptors CD247 and FCER1G to trigger potent NK-cell degranulation and tumor cell lysis, thereby serving as a critical initiator of natural cytotoxicity within the innate immune response.

Picture

FC

Flow cytometric analysis of Human CD335 expression on Human PBMC. Human PBMC were stained with APC Mouse Anti-Human CD56 Antibody and either Biotin Mouse IgG1, κ Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD335 Antibody (right panel) at 1.25 μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.