Flow cytometric analysis of Human CD270 expression on human PBMCs (human peripheral blood mononuclear cells). Human PBMCs were stained with Brilliant Violet 421™ Mouse Anti-Human CD19 Antibody and either Biotin Mouse IgG1, k Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD270 Antibody (right panel) at 5 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
Biotin Mouse Anti-Human CD270 Antibody (S-2915)
Biotin Mouse Anti-Human CD270 Antibody (S-2915)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD270 |
| Synonyms | Tumor necrosis factor receptor superfamily member 14; Herpes virus entry mediator A (Herpesvirus entry mediator A; HveA); Tumor necrosis factor receptor-like 2 (TR2); HVEA; HVEM; TNFRSF14 |
| Location | Cell membrane |
| Accession | Q92956 |
| Clone Number | S-2915 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Isotype Control | S0B5431 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD270, also known as TNFRSF14 or Herpesvirus Entry Mediator (HVEM), is a member of the TNF-receptor superfamily. It is a type I transmembrane protein that plays a crucial role in mediating the entry of herpes simplex virus into cells through its interaction with the viral envelope glycoprotein D (gD). The cytoplasmic region of CD270 binds to several TRAF family members, which are involved in signal transduction pathways that activate the immune response. CD270 is widely expressed in various tissues, including blood vessels, brain, heart, and immune cells such as T cells and B cells. Its interactions with ligands like LIGHT (TNFSF14) and LTα are also important for immune regulation .
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