Flow cytometric analysis of Human CD2 expression on human peripheral blood leukocytes. Human peripheral blood leukocytes were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 Antibody and either Biotin Mouse IgG1, κ Isotype Control (left panel) or SDT Biotin Mouse Anti- Human CD2 Antibody (right panel) at 5 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Biotin Mouse Anti-Human CD2 Antibody (RPA-2.10)
Biotin Mouse Anti-Human CD2 Antibody (RPA-2.10)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD2 |
| Synonyms | T-cell surface antigen CD2; Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; SRBC |
| Location | Cell membrane |
| Accession | P06729 |
| Clone Number | RPA-2.10 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Isotype Control | S0B5431 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood leukocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD2, also known as the T-cell surface antigen CD2, is a transmembrane glycoprotein primarily expressed on the surface of T cells and natural killer (NK) cells. It belongs to the immunoglobulin superfamily and plays a crucial role in mediating cell adhesion and activation. CD2's principal ligand is CD58 (LFA-3), which is expressed on antigen-presenting cells and other immune cells. The interaction between CD2 and CD58 facilitates T-cell activation and enhances the immune response. Structurally, CD2 consists of an extracellular domain responsible for ligand binding, a transmembrane domain anchoring it to the cell membrane, and an intracellular domain involved in signal transduction.
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