Flow cytometric analysis of Human CD197 expression on Human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 Antibody and either Biotin Mouse IgG2a, κ Isotype Control (Left panel) or SDT Biotin Mouse Anti-Human CD197 Antibody (Right panel) at 5 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Biotin Mouse Anti-Human CD197 Antibody (S-R704)
Biotin Mouse Anti-Human CD197 Antibody (S-R704)
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Product Details
Product Details
Product Specification
| Synonyms | C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR-7; BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1 (EBI1; EBV-induced G-protein coupled receptor 1); MIP-3 beta receptor; CMKBR7; EBI1; EVI1; CCR7 |
| Location | Cell membrane |
| Accession | P32248 |
| Clone Number | S-R704 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD197, also known as CCR7 (C-C motif chemokine receptor 7) or BLR2, is a G protein-coupled receptor that plays a crucial role in immune cell migration and function. It is expressed on activated T cells, B cells, and dendritic cells, and is significantly upregulated in B cells following Epstein-Barr virus infection. CD197 binds chemokines such as CCL19 and CCL21, mediating the migration of memory T cells to lymph nodes and the maturation of dendritic cells. It also serves as a biomarker for certain immune responses and is involved in the regulation of T cell homeostasis and chronic inflammation.
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