Biotin Mouse Anti-Human CD196 Antibody (S-R645)

CD196, also known as CCR6 (C-C chemokine receptor type 6), is a G protein-coupled receptor primarily expressed on specific subsets of immune cells including memory T cells (particularly Th17 and regulatory T cells), immature dendritic cells, and B cells, where it serves as the exclusive receptor for the chemokine CCL20 (also called MIP-3α). This signaling axis plays a pivotal role in directing the migration of these leukocytes to inflammatory sites and secondary lymphoid organs, especially those rich in CCL20 such as the skin, lung, and mucosal tissues of the gut, thereby facilitating critical immune surveillance and the organization of adaptive immune responses. Beyond its physiological function in homeostasis and inflammation, CD196 is significantly implicated in various pathological conditions, acting as a key marker for Th17-mediated autoimmune diseases like rheumatoid arthritis, psoriasis, and multiple sclerosis, while also being exploited by certain cancers and HIV strains for cell entry or metastatic spread, making it a promising therapeutic target for modulating immune trafficking in chronic inflammatory disorders and oncology.