Flow cytometric analysis of human CD192 expression on human PBMCs (human peripheral blood mononuclear cells). Human PBMCs were stained with Brilliant Violet 421™ Mouse Anti-Human CD14 Antibody and either Biotin Mouse IgG2a, k Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD192 Antibody (right panel) at 5 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
Biotin Mouse Anti-Human CD192 Antibody (S-2971)
Biotin Mouse Anti-Human CD192 Antibody (S-2971)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD192 |
| Synonyms | C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; Monocyte chemoattractant protein 1 receptor (MCP-1-R); CMKBR2 |
| Location | Cell membrane |
| Accession | P41597 |
| Clone Number | S-2971 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Isotype Control | S0B5432 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD192, also called CCR2, is a 42 kDa seven-transmembrane G-protein-coupled receptor expressed mainly on monocytes, macrophages and basophils that binds the chemokines MCP-1 (CCL2), MCP-3 (CCL7) and MCP-4 (CCL13), triggers intracellular calcium flux and inhibition of adenylyl cyclase, thereby directing chemotaxis and bone marrow homeostasis, and has been implicated in inflammatory diseases such as rheumatoid arthritis, atherosclerosis and cancer as well as serving as an alternative HIV-1 coreceptor with CD4.
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