Flow cytometric analysis of human CD158 expression on Human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Allophycocyanin Mouse Anti-Human CD56 Antibody and either Biotin Mouse IgG2b, κ Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD158 Antibody (right panel) at 5 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Biotin Mouse Anti-Human CD158 Antibody (S-2918)
Biotin Mouse Anti-Human CD158 Antibody (S-2918)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD158 |
| Synonyms | Killer cell immunoglobulin-like receptor 2DL1; CD158 antigen-like family member A; Natural killer-associated transcript 1 (NKAT-1); p58 natural killer cell receptor clones CL-42/47.11 (p58 NK receptor CL-42/47.11); p58.1 MHC class-I-specific NK receptor; CD158a; NKAT1; KIR2DL1 |
| Location | Cell membrane |
| Accession | P43626 |
| Clone Number | S-2918 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD158, also known as killer-cell immunoglobulin-like receptor (KIR), is a polymorphic type I transmembrane glycoprotein expressed chiefly on natural killer (NK) cells and subsets of T cells that recognizes specific HLA class I allotypes (HLA-A, -B or -C) and transmits either inhibitory or activating signals—depending on whether its cytoplasmic tail contains ITIMs or associates with the ITAM-bearing adaptor DAP12—to regulate cytotoxic activity, thereby serving as a critical immune checkpoint whose blockade is being explored clinically to unleash NK-cell mediated anti-tumor responses.
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