Flow cytometric analysis of CD137 expression in activated human PBMC (human peripheral blood mononuclear cell). PHA-activated (2 days) human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD25 Antibody and either Biotin Mouse IgG1, k Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD137 Antibody (right panel) at 1.25 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software
Biotin Mouse Anti-Human CD137 Antibody (4B4-1)
Biotin Mouse Anti-Human CD137 Antibody (4B4-1)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD137 |
| Synonyms | Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; ILA; TNFRSF9 |
| Location | Cell membrane |
| Accession | Q07011 |
| Clone Number | 4B4-1 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu, RhMk, CyMk |
| Positive Sample | PHA-activated human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD137, also known as 4-1BB, is a co-stimulatory molecule expressed on the surface of activated T cells and natural killer cells. It plays a crucial role in enhancing the immune response by providing additional signals that promote T cell proliferation, survival, and cytokine production. CD137 is a member of the tumor necrosis factor receptor superfamily and its ligand, CD137L, is primarily found on antigen-presenting cells. The interaction between CD137 and CD137L helps to sustain the activation of T cells and supports the development of long-lasting immune responses, making it an important target for immunotherapy in cancer treatment and other diseases where modulation of the immune system is beneficial.
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