2μg (R: reducing condition, N: non-reducing condition).
BD-2 Protein, Human
BD-2 Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Defensin beta 4A; Beta-defensin 2; Defensin, beta 2; Skin-antimicrobial peptide 1 (SAP1); |
| Accession | O15263 |
| Amino Acid Sequence | Gly24-Pro64 |
| Expression System | E.coli |
| Molecular Weight | 5 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Science. 2002 Nov 1;298(5595):1025-9. |
Background
Beta-defensin 2 is a key component of the innate immune system, known for its antimicrobial properties and immunomodulatory functions. It is produced by various epithelial cells in response to microbial infections and plays a crucial role in host defense against pathogens. Beta-defensin 2 exhibits potent antimicrobial activity against a wide range of microorganisms, including bacteria, fungi, and viruses, by disrupting their cell membranes. In addition to its direct antimicrobial effects, beta-defensin 2 also functions as a chemoattractant for immune cells, such as neutrophils, monocytes, and dendritic cells, promoting their recruitment to sites of infection. Furthermore, beta-defensin 2 can modulate inflammatory responses by regulating cytokine production and promoting wound healing.
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SDS-PAGE
RP-HPLC
>95% as determined by RP-HPLC.
ELISA
Measured by its binding ability in a functional ELISA. When Anti-BD-2 Recombinant Antibody is immobilized 0.5µg/mL (100µL/well), Recombinant Human BD-2 binds with an EC50 of 0.8-1.2ng/ml.
