BACH1 Recombinant Rabbit mAb (S-4294-25)

BACH1 (BTB and CNC homolog 1) is a transcription factor belonging to the basic leucine zipper (bZIP) family and is a member of the BACH family. It plays a critical role in regulating oxidative stress, heme metabolism, and tumor progression through transcriptional repression. BACH1 typically forms heterodimers with Maf-related proteins and binds to MARE elements (Maf recognition elements) in the promoter regions of target genes, thereby suppressing downstream gene transcription. Its major target genes include heme oxygenase-1 (HO-1, HMOX1), which encodes an antioxidant enzyme, as well as genes involved in the regulation of globin gene expression. Thus, BACH1 plays a central role in cellular defense against oxidative damage and in maintaining heme homeostasis. When intracellular heme levels rise, heme directly binds to BACH1 and promotes its nuclear export and proteasomal degradation, thereby relieving the repression of target genes such as HO-1 and initiating antioxidant defense responses. In recent years, the role of BACH1 in tumor biology has garnered extensive attention, with studies revealing that its overexpression is associated with enhanced invasiveness, chemoresistance, and poor prognosis in various malignancies including breast cancer, lung cancer, and prostate cancer. The underlying mechanisms involve the regulation of epithelial-mesenchymal transition (EMT), metabolic reprogramming, and cancer stem cell properties. Furthermore, BACH1 is also involved in regulating immune cell differentiation, inflammatory responses, and angiogenesis, positioning it as a highly promising therapeutic target for various diseases (such as ischemic cardiovascular diseases and neurodegenerative disorders), and multiple small-molecule BACH1 inhibitors are currently under development.