ATGL Recombinant Rabbit mAb (S-5284)

ATGL (adipose triglyceride lipase, also known as PNPLA2) is the rate-limiting enzyme that initiates the lipolysis process in animal cells, primarily responsible for catalyzing the hydrolysis of triglycerides into diglycerides and free fatty acids—this initial step represents the most critical regulatory node in the entire lipolytic cascade. When energy demand increases, ATGL activity is finely regulated: its intrinsic activity is significantly enhanced by binding to CGI-58 protein; however, when cells are in a high-energy state, G0S2 protein binds to ATGL and inhibits its function, while phosphorylation modifications also play an important role in modulating its activity. ATGL not only governs energy metabolism in adipose tissue but also regulates lipid homeostasis in various organs including the heart, liver, and skeletal muscle. Dysfunction of ATGL is closely associated with multiple metabolic diseases such as obesity, insulin resistance, fatty liver disease, and myocardial lipotoxicity, making it an important potential therapeutic target for metabolic syndrome and cardiovascular diseases.