Flow cytometric analysis of C57BL/6 mouse splenocytes labelling Mouse NKG2D1 antibody at 1/200 dilution (1 μg) / (Right panel) compared with a Armenian hamster IgG Isotype Control / (Left panel). Followed by Anti-Armenian Hamster IgG (H+L) biotin and Sav-PE. Then cells were stained with NK1.1 - Alexa Fluor® 647 Antibody separately.
Armenian hamster Anti-Mouse NKG2D Antibody (S-3681)
Armenian hamster Anti-Mouse NKG2D Antibody (S-3681)
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Product Details
Product Details
Product Specification
| Host | Armenian hamster |
| Antigen | NKG2D |
| Synonyms | NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD314; Nkg2d; Klrk1 |
| Location | Cell membrane |
| Accession | O54709 |
| Clone Number | S-3681 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
NKG2D is a type II transmembrane C-type lectin-like receptor expressed as a disulfide-linked homodimer on virtually all human and mouse NK cells, γδ T cells, and CD8+ αβ T cells; upon engagement by stress-inducible MHC class I–related ligands (MICA/B, ULBPs in humans; Rae-1, H60, Mult1 in mice) it couples to the DAP10 (and in mouse also DAP12) adaptor to deliver phosphotyrosine signals that powerfully lower activation thresholds, costimulate cytotoxicity, and drive proliferation and cytokine release, thereby forming a central surveillance axis that eliminates transformed, infected, or otherwise stressed cells but also contributes to immune-mediated pathologies when ligand expression becomes chronic.
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