Flow cytometric analysis of C57BL/6 mouse splenocytes labelling Mouse CD103 antibody at 1/200 (1 μg) dilution. Followed by Anti-Armenian Hamster IgG (H+L) biotin and Sav-PE. Then cells were stained with CD3 - Brilliant Violet 421™ antibody separately.
Armenian hamster Anti-Mouse CD103 Antibody (S-R692)
Armenian hamster Anti-Mouse CD103 Antibody (S-R692)
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Product Details
Product Details
Product Specification
| Host | Armenian hamster |
| Antigen | CD103 |
| Synonyms | Integrin alpha-E; Integrin alpha M290; Itgae |
| Location | Membrane |
| Accession | Q60677 |
| Clone Number | S-R692 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
CD103, also known as integrin αEβ7, is a transmembrane heterodimer complex primarily expressed on the surface of various immune cells, including intraepithelial lymphocytes (IELs), tissue-resident memory T cells (TRM), and dendritic cells. It plays a crucial role in cell adhesion and migration through its interaction with E-cadherin, a cellular adhesion molecule found on epithelial cells. CD103 is a hallmark of immune cells residing in mucosal tissues such as the gut, lung, and skin, and is involved in immune surveillance and regulation. In cancer, CD103+ immune cells are associated with immune checkpoint pathways and can serve as predictive markers for immunotherapy response in various malignancies.
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