Flow cytometric analysis of Human CD269 expression on U266B1 cells. Cells from the U266B1 (Human multiple myeloma B lymphocyte, Right) or Jurkat (Human T cell leukemia T lymphocyte, Left) was stained with either APC Mouse IgG2a, κ Isotype Control (Black line histogram) or SDT APC Mouse Anti-Human CD269 Antibody (Red line histogram) at 5 μl/test, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
APC Mouse Anti-Human CD269 Antibody (S-R559)
APC Mouse Anti-Human CD269 Antibody (S-R559)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD269 |
| Synonyms | Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; BCM; BCMA; TNFRSF17 |
| Location | Cell membrane |
| Accession | Q02223 |
| Clone Number | S-R559 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | U266B1 |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD269, also known as B-cell maturation antigen (BCMA) or tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a type III transmembrane receptor of the TNF-receptor superfamily encoded by the TNFRSF17 gene, expressed predominantly on mature B cells, plasmablasts, and plasma cells, where it binds ligands BAFF and APRIL to activate NF-κB and MAPK8/JNK pathways, thereby promoting B-cell survival, differentiation, and immunoglobulin production while playing a crucial role in autoimmune responses.
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