Flow cytometric analysis of Human CD158b expression on human peripheral blood Leukocytes. Human peripheral blood Leukocytes were stained with PE Mouse Anti-Human CD56 Antibody and either APC Mouse IgG2a, κ Isotype Control (Left panel) or SDT APC Mouse Anti-Human CD158b/j Antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
APC Mouse Anti-Human CD158b/j Antibody (S-2917)
APC Mouse Anti-Human CD158b/j Antibody (S-2917)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD158b/j |
| Synonyms | CD158b1; KIR2DL2; CD158B1; NKAT2a; NKAT2b; CD158b2; KIR2DL3; CD158B2; KIRCL23; NKAT2; CD158j; KIR2DS2; CD158J; NKAT5 |
| Location | Endoplasmic reticulum |
| Accession | P43627、P43628、P43631 |
| Clone Number | S-2917 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood Leukocytes |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD158b/j is a collective designation for the killer-cell immunoglobulin-like receptors (KIR2DL2, KIR2DL3 and KIR2DS2), 50–58 kDa type-I transmembrane glycoproteins expressed chiefly on natural killer cells and minor T-cell subsets; each molecule carries two extracellular Ig-like C2 domains that recognize distinct HLA-C alleles (HLA-Cw1/3/7 for the inhibitory forms), and while the long-tailed CD158b variants (KIR2DL2/L3) deliver inhibitory signals via dual cytoplasmic ITIM motifs to prevent target-cell lysis, the short-tailed CD158j variant (KIR2DS2) can trigger activation, thereby collectively fine-tuning innate cytotoxic responses and influencing immune escape in infection, transplantation and cancer.
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