APC-Cy7 Armenian hamster Anti-Mouse/Human KLRG1 Antibody (2F1)

Killer cell lectin-like receptor G1 (KLRG1) is a 30–35 kDa C-type lectin-like inhibitory receptor expressed predominantly on the surface of late-differentiated effector and effector-memory CD8⁺ T, NK, NKT and some CD4⁺ T cells, where its engagement by ubiquitous E-, N- or R-cadherins on epithelial or vascular structures delivers SHP-1/2-dependent signals that terminate calcium flux, cytotoxic granule release and proliferation, thereby acting as a crucial “brake” on acute and chronic immune responses; up-regulated by repeated antigen or IL-2/IL-15 stimulation, KLRG1 demarcates short-lived effector cells destined for apoptosis versus long-lived memory precursors, and its genetic or antibody blockade enhances viral clearance, tumor control and vaccine efficacy, while its sustained expression correlates with T-cell exhaustion, immunosenescence and impaired survival in infections, cancer and autoimmunity, positioning KLRG1 as a key biomarker and therapeutic target for immune rejuvenation.