Flow cytometric analysis of Mouse CD11c expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with FITC Rat Anti-Mouse I-A/I-E Antibody (S0B1661) at 5μl/test and either APC Armenian Hamster Isotype Control (Left panel) or SDT APC Armenian Hamster Anti-Mouse CD11c Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
APC Armenian Hamster Anti-Mouse CD11c Antibody (S-R518)
APC Armenian Hamster Anti-Mouse CD11c Antibody (S-R518)
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Product Details
Product Details
Product Specification
| Host | Armenian hamster |
| Antigen | CD11c |
| Synonyms | Integrin alpha-X; CD11 antigen-like family member C; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; Itgax |
| Location | Membrane |
| Accession | Q9QXH4 |
| Clone Number | S-R518 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD11c, also known as integrin alpha X or ITGAX, is a type I transmembrane glycoprotein and a member of the β2 integrin family. It forms a heterodimer with CD18 to create the complement receptor 4 (CR4), which is involved in various immune functions. CD11c is highly expressed on myeloid dendritic cells (DCs), monocytes, macrophages, granulocytes, and subsets of T and B cells. It plays a crucial role in cell adhesion, migration, and phagocytosis, and is essential for the activation of CD4+ and CD8+ T cells by DCs. Additionally, CD11c is involved in the regulation of hematopoietic stem and progenitor cells under stress conditions. It is widely used as a marker for DCs in immunological research and clinical applications.
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