Anti-Mouse C11D5.3 scFv (Anti-BCMA CAR-T) Recombinant Rabbit mAb (Alexa Fluor® 488 Conjugate) (S-5414)

This antibody is a critical research reagent specifically designed for detecting and evaluating BCMA-targeting CAR-T cells. Its core mechanism of action is to serve as an anti-idiotypic antibody that can specifically recognize and bind with high affinity to the C11D5.3 single-chain variable fragment (scFv) antigen recognition domain displayed on the surface of CAR-T cells. The C11D5.3 clone itself is a mouse monoclonal antibody targeting B-cell maturation antigen (BCMA), and its scFv format is a commonly used component for constructing BCMA-specific CARs, having been widely applied in numerous CAR-T clinical trials and utilized in FDA-approved therapies. Therefore, the Anti-Mouse C11D5.3 scFv antibody is often employed as a companion diagnostic reagent in CAR-T therapy clinical studies to detect the survival, proliferation, and surface CAR molecule expression levels of infused CAR-T cells in patients via methods such as flow cytometry, serving as an important tool for evaluating CAR-T pharmacokinetics and pharmacodynamics.