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Anti-Human Nectin-4 Monoclonal Antibody (Enfortumab)

Anti-Human Nectin-4 Monoclonal Antibody (Enfortumab)

Catalog Number: S0B7089 Application: Blocking of Nectin-4 signaling Functional assays Reactivity: Hu Conjugation: Unconjugated Brand: Starter
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$335 USD
$335 USD
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Product Details

Product Specification


Host Human
Antigen Nectin-4
Synonyms Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4Imported; Poliovirus receptor-related protein 4; LNIR; PRR4; PVRL4; NECTIN4
Location Secreted, Cell membrane, Cell junction
Accession Q96NY8
Antibody Type Recombinant mAb
Isotype IgG1,k
Application Blocking of Nectin-4 signaling Functional assays
Reactivity Hu
Purification Protein A
Concentration 5 mg/ml
Endotoxin <1EU/mg
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, containing no preservative
Stability & Storage

2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.

Background

Nectin-4 (Poliovirus Receptor Related 4) is a transmembrane protein expressed on the cell surface that primarily functions during embryonic development, with minimal expression in healthy adult tissues. However, it is found to be aberrantly overexpressed in various malignancies—such as urothelial carcinoma, breast cancer, and lung cancer—where it correlates with tumor proliferation, metastasis, and poor prognosis, making it a highly promising therapeutic target. Targeted therapies developed against Nectin-4, particularly antibody-drug conjugates (ADCs), can precisely recognize and bind to tumor cells to deliver cytotoxic payloads, demonstrating significant clinical efficacy in treating urothelial carcinoma

Picture

Western Blot

WB result of Anti-Human Nectin-4 Monoclonal Antibody (Enfortumab)
Primary antibody: Anti-Human Nectin-4 Monoclonal Antibody (Enfortumab) at 1/1000 dilution
Lane 1: Nectin-4 His Tag Protein, Human 1 µg
Lane 2: Nectin-4 His Tag Protein, Cynomolgus 1 µg
Secondary antibody: Goat Anti- human IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 55 kDa
Observed MW: 38-50 kDa

ELISA

Immobilized Nectin-4 His Tag Protein, Human(UA010020) can bind Enfortumab. The EC50 for this effect is 11.44 ng/mL.

Immobilized Nectin-4 His Tag Protein, Cynomolgus(UA010730) can bind Enfortumab. The EC50 for this effect is 15.82 ng/mL.