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Anti-Gulgafafusp alfa Monoclonal Antibody (Glutazumab)

Anti-Gulgafafusp alfa Monoclonal Antibody (Glutazumab)

Catalog Number: UA016034 Brand: UA BIOSCIENCE
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$80 USD
$80 USD
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Product Details

Product Specification


Host Human
Synonyms Gulgafafusp alfa, Glutazumab
Concentration 2mg/mL
Expression System HEK293
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, PH7.4
Stability & Storage

2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
Reference

1. Drucker DJ. GLP-1-based therapies for diabetes, obesity and beyond. Nat Rev Drug Discov. 2025 Aug;24(8):631-650. doi: 10.1038/s41573-025-01183-8. Epub 2025 Apr 25. Erratum in: Nat Rev Drug Discov. 2025 Jul;24(7):570. 
2.Pan H, Su Y, Xie Y, Wang W, Qiu W, Chen W, Lu W, Lu Z, Wang W, Shang A. Everestmab, a novel long-acting GLP-1/anti GLP-1R nanobody fusion protein, exerts potent anti-diabetic effects. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):854-866.

Background

Gulgafafusp alfa is a humanized IgG2κ monoclonal antibody fusion protein targeting the glucagon-like peptide-1 receptor (GLP-1R) for the treatment of type 2 diabetes mellitus and obesity. This protein is engineered through genetic fusion of a GLP-1(7-35) agonist fragment to the Fc region of an anti-GLP-1R antibody, forming a unique "antibody-ligand" bifunctional structure: the antibody moiety specifically binds to GLP-1R, while the GLP-1 fragment activates downstream cAMP signaling pathways. Through synergistic dual receptor binding sites, this design significantly enhances binding affinity and prolongs half-life. As a long-acting GLP-1R agonist, Gulgafafusp alfa promotes glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and increases satiety, thereby achieving sustained glycemic control and weight reduction effects.

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ELISA

Immobilized Unconjugated GLP-1R His&Avi Tag, Human (Cat. No. UA016019) at 1.0μg/mL (100μL/well) can bind Anti-Gulgafafusp alfa Monoclonal Antibody (Glutazumab) (Cat. No. UA016034) with EC50 of 0.72-0.90 ng/mL.