1μg (R: reducing condition, N:non-reducing condition).
Angiopoietin-like 3/ANGPTL3 His Tag Protein, Human
Angiopoietin-like 3/ANGPTL3 His Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | ANGPTL3, ANGPT5, ANG-5, Angiopoietin-5, FHBL2 |
| Accession | Q9Y5C1-1 |
| Amino Acid Sequence | Ser17-Glu460 with His Tag at the C-terminus |
| Expression System | HEK293 |
| Molecular Weight | 60-75 kDa (Reducing) |
| Purity | > 95 % as determined by SDS-PAGE & RP-HPLC; > 90 % as determined by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4,5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Arch Esp Urol. 2025 Jan;78(1):84-92. |
Background
ANGPTL3, also known as angiopoietin-related protein 3 or angiopoietin-5 (ANGPT5), is a secreted factor in the angiopoietin-like family. Predominantly expressed in the liver, it features a signal peptide, an N-terminal coiled-coil domain, and a C-terminal fibrinogen-like domain. The fibrinogen-like domain binds alpha-5/beta-3 integrins, promoting endothelial cell adhesion and migration, and may regulate angiogenesis. ANGPTL3 also inhibits lipoprotein lipase and endothelial lipase, increasing plasma triglycerides and HDL cholesterol in rodents. By blocking endothelial lipase, it raises HDL-phospholipid levels, enhancing cholesterol efflux.
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SDS-PAGE
SEC-HPLC
The purity of Angiopoietin-like 3/ANGPTL3 His Tag Protein, Human is more than 90% determined by SEC-HPLC.
ELISA
Immobilized Angiopoietin-like 3/ANGPTL3 His Tag Protein, Human (Cat. No. UA011204) at 2.0μg/mL (100μL/well) can bind ANGPTL3 Recombinant Rabbit mAb (SDT-425-59) (Cat. No. S0B3204) with EC50 of 0.96-1.35ng/mL.
