Amyloid beta 1-42 Recombinant Rabbit mAb (SDT-1549-130)

Amyloid beta 1-42 (Aβ1-42) is a peptide composed of 42 amino acids, derived from the enzymatic cleavage of the amyloid precursor protein (APP). It is the primary component of amyloid plaques in Alzheimer's disease (AD) and is highly hydrophobic and prone to aggregation. Aβ1-42 is more likely than the more common Aβ1-40 to form toxic oligomers and fibrils, which are believed to play a key role in the pathological process of AD by disrupting neuronal function, triggering inflammatory responses, and causing synaptic dysfunction. The abnormal accumulation and aggregation of Aβ1-42 is one of the early pathological hallmarks of AD and a critical target for research and treatment of the disease.